Parent Project Muscular Dystrophy (PPMD) and Foundation to Eradicate Duchenne (FED) today announced that they will award ReveraGen BioPharma (ReveraGen) a $1 million grant. The grant will help fund ReveraGen’s VBP15, a combined action drug that addresses multiple levels of the muscle disease Duchenne muscular dystrophy (Duchenne).

ReveraGen BioPharma today announced the start of a Phase 1, first-in-human, clinical trial of a novel dissociative steroidal drug, VBP15, under development for Duchenne muscular dystrophy. Recruitment in the trial is underway, with the initial doses in the first volunteers having been received.

“Glucocorticoids are a mainstay of therapeutics for Duchenne muscular dystrophy, but the side effect profiles detract from patient quality of life, and VBP15 promises to retain or increase efficacy while reducing side effect profiles,” said Eric Hoffman, CEO of ReveraGen BioPharma.

We are delighted to announce that the project titled ‘Definition of pharmacodynamics biomarker panel in a Phase 2a clinical trial of VBP15 in DMD’ has successfully completed our peer-review process. The aim of this proposal is to address the increasing concern that there aren’t enough Duchenne patients available to adequately satisfy the needs of the drug development programs in a timely manner. An acknowledged approach towards this end is the development of robust pharmacodynamics biomarker panels. These allow testing of the effects of a drug on much more acute time frames (2-4 weeks), and are considered more quantitative and less subject to bias.